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Ciprofloxacin and levofloxacin showed some LC3B conversion in the first day of treatment, however this was not accompanied by P62 degradation or maintained in subsequent treatment days (Supplementary Figure S3)

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Since B12 shots contain much more B12 than the body can readily use or store, there is a lot of waste

These side effects are generally mild and might not occur at all

However, clinically relevant immunogenicity is relatively uncommon with most approved peptide drugs

When injections are the right choice When blood tests or clinical context indicate deficiency or malabsorption, intramuscular B12 is an appropriate and often necessary treatment